PMC

Owner perceived time from initial signs of late‐onset laryngeal paralysis (LoLP) to a decrease in their dog's quality of life (QOL), and owner perceived contribution of LoLP to their dog's death. (a) The time from which owners first noticed signs of LoLP to when they felt their dog's QOL was affected by the condition, a proxy for disease progression. The majority of owners felt that LoLP progressed to negatively impact their dog's QOL within 2 years of diagnosis. The response “no effect” refers to owners who did not feel LoLP affected their dog's QOL. “Late‐diagnosis” refers to responses from owners who did not know their dog had late‐onset laryngeal paralysis until the disease was severe. All dogs n = 76; Arytenoid lateralization n = 33; No surgical intervention n = 43. (b) The degree to which owners felt LoLP contributed to their dog's death is shown. Among all dog owners, 20 (47%) felt that LoLP was at least a large contributing factor to their dog's death. All dogs n = 42; Arytenoid lateralization n = 20; No surgical intervention n = 22. Results are presented as a percent of dogs from each group

Host and homografted liver 28 days after auxiliary hepatic homotransplantation. (a, above) Recipient dog’s own liver which is essentially normal. (b) Homograft which was revascularized in the lower abdomen. Note the moderate amount of cellular infiltrate of the portal area. The parenchyma has many areas of focal necrosis. Total removal of the recipient animal’s own liver was carried out at the time of these biopsies. The heterotopic transplant did not sustain life, and the dog died two days later. H & E stain ( × 80).

“First Stage of Cruelty” by William Hogarth (1750), the first plate from “The Four Stages of Cruelty” series, which describes the escalating violent behavior that follows childhood cruelty to animals to an adulthood of criminal life. In this scene, two boys plunge an arrow into the rectum of a dog, while another boy, most likely the pet’s owner, pleads with them to stop. Meanwhile, some boys are burning the eye of a bird, while others tie bones to a dog’s tail. Also, some boys play “cock-throwing” (a popular sport in eighteenth-century England, consisting of throwing stones or bottles at a cockerel tied to a stake) while others hang fighting cats, and others even throw animals from windows. Source: ^©Victoria and Albert Museum, London.

Owner responses to questions pertaining to their dog's activity with late‐onset laryngeal paralysis. (a) When owners were asked whether they agreed, were neutral or disagreed with the statement “My pet's breathing prevents activity,” nearly half of owners agreed. Owners of dogs that had unilateral arytenoid lateralization were more likely to respond that they did not feel that breathing affected their dog's activity, when compared with owners whose dogs did not have surgical intervention. (b) When owners were asked whether they agreed, were neutral or disagreed with the statement “My pet is able to undertake activities he/she wants,” the most common response was neutral, and no difference in responses were seen between groups. All dogs n = 76; Arytenoid lateralization n = 33; No surgical intervention n = 43. Results are presented as a percent of dogs from each group